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Antioxidant levels and prostate cancer risk

The new study proved that antioxidant levels are responsible for prostate cancer risk in some men.
US researchers say that high levels of selenium, vitamin E and the tomato carotenoid lycopene reduce prostate cancer in one out of every four Caucasian males, or those who inherit particularly sensitive to oxidative stress specific genetic variation.

According the study of Cancer Research for men with low levels of these vitamins and minerals their risk of aggressive prostate increases substantially.

Dr Haojie Li, a researcher at the Brigham and Women’s Hospital and Harvard Medical School provides evidence that oxidative stress may be one of the important mechanisms for prostate cancer development and progression. Adequate intake of antioxidants, such as selenium, lycopene and vitamin E, may help prevent prostate cancer.

The researches from the Physicians Health Study are based on an analysis of 567 men with prostate cancer and 764 cancer-free men.

The initial goal of this study was to assess the effect of aspirin and vitamins (beta-carotene) on men’s health. Team checked variants of the gene that codes for manganese superoxide dismutatase (MnSOD).
The MnSOD gene is passed from parents to offspring in one of three forms: VV, VA or AA.

Researchers found that men with the MnSOD VV or VA genotype, people with the AA genotype are more sensitive to the antioxidant status. Men with the AA genotype are more susceptible to prostate cancer if their antioxidant and vitamins levels are low.

The study’s results found that a quarter of the men in the study carried the MnSOD AA genotype, half carried the VA genotype, and the remaining quarter carried the VV genotype.

The results indicated that the VA and VV men were at equivalent risk for developing prostate cancer across all levels of antioxidants in their blood.

Prostate cancer is most often cancer type in industrial countries. It affects more than 500,000 men worldwide every year.

Similar to prostate cancer link between dietary antioxidants and the variations in the MnSOD gene have previously been noticed in risk of breast cancer.


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