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Vitamin B12 deficiency lead to pernicious anemia

Vitamin B12 is one of the important nutrients in hemoglobin synthesis process, the oxygen carrying pigment in blood. Vitamin B12 is needed for DNA synthesis in the rapidly dividing cells of the bone marrow. Deficiency of vitamin B12 or folate can lead to the production of large, immature, hemoglobin-poor red blood cells.
Pernicious anemia results from inadequate absorption of vitamin B12, which can be caused by damaged stomach cells. It is most common in those over 60 years of age.
Deficiency of vitamin B12 is not usually from lack of intake, but rather from lack of absorption. Lack of intrinsic factor can also prevent absorption.
Even a more than adequate dietary intake will not help because the vitamin B12 is not absorbed through the intestines.
With pernicious anemia, Vitamin B12 must be injected or absorbed through membranes directly into the bloodstream via a nasal spray or absorbed from under the tongue.
It may take several years to develop deficiency symptoms as vitamin B12 is efficiently recycled. Whether the deficiency is from poor absorption or from a diet low in animal products, onset of symptoms is typically slow.

Symptoms of pernicious anemia

The following symptoms may indicate pernicious anemia: shortness of breath, fatigue, pallor, rapid heart rate, loss of appetite, diarrhea, tingling and numbness of hands and feet, sore mouth, unsteady gait, especially in the dark, tongue problems, smell, impaired, gums, bleeding, positive Babinski’s, reflex , loss of deep tendon reflexes, personality changes, “megaloblastic madness”.


Pernicious anemia outcome is usually excellent with treatment. Monthly vitamin B12 injections are the definitive treatment to correct the vitamin B12. There is also a preparation of vitamin B12 that may be given intranasally (in the nose). A well-balanced diet is essential to provide other elements such as folic acid, iron, and vitamin C for healthy blood cell development.

Vitamin B12 in food

Vitamin B12 is found only in foods made from animal products, such as meat, dairy products, and eggs.
Vitamin B12 is easily lost through leaching into water while cooking. One unusual thing about vitamin B12 is that microwave cooking inactivates it. Cooking in the oven or in soups and stews preserves the most vitamin B12.

Kal's Vitamin B12 Spray 2500mcg 2oz Kal’s Vitamin B12 Spray 2500mcg 2oz

Directions: Shake well. As a dietary supplement, hold nozzle approximately 1″ from mouth and spray under tongue 1-2 times daily. Hold under tongue for 20 seconds, then swallow. May be taken with or without meals. Store in a cool, dry place. Other Ingredients: Glycerin, USP Purified Water, Natural Grape Flavors, Potassium Sorbate, Citric Acid, Lecithin and Natural Mixed Tocopherols

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