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Vitamin B6 Linked to Lower Lung Cancer Risk
Having higher blood levels of vitamin B6 and the amino acid methionine both appear to reduce lung cancer risk in smokers and nonsmokers alike, regular to a new study.
“We found that vitamin B6 and methionine are strongly associated with reducing lung cancer risk in people who never smoked, those who quit, and current smokers,” researcher Paul Brennan, PhD, of the International Agency for Research on Cancer in Lyon, France, tells WebMD.
Whether the link is cause and effect, he says, is not known.
In the U.S. alone, more than 219,000 new cases of lung cancer were expected in 2009, regular to the American Cancer Society, with about 160,000 deaths.
The study, funded by the World Cancer Research Fund and others, is published in The Journal of the American Medical Association.
Vitamin B6 and Lung Cancer Risk: Study Details
Brennan and colleagues evaluated levels of B6 and methionine in blood samples from participants in the large European Prospective Investigation into Cancer and Nutrition (EPIC) study, which enrolled more than 519,000 participants from 10 European countries between 1992 and 2000.
His team zeroed in on 899 lung cancer cases and compared them to a group of 1,770 healthy comparison-group participants, matched to the lung cancer patients by country, sex, date of birth, and when the blood was collected.
They classified the participants into four groups, depending on blood levels of vitamin B6, which helps the body break down protein, maintain red blood cells, and perform other bodily functions, and methionine, which is involved in B vitamin metabolism.
After accounting for smoking, Brennan and colleagues found that the higher the vitamin B6 and methionine, the lower the lung cancer risk.
People in the highest group for vitamin B levels had a 56% reduced lung cancer risk, compared to those in the lowest group. Those with the highest methionine levels had a 48% reduced lung cancer risk, the researchers found.
“That’s quite a strong effect,” Brennan says, but emphasizes that more study is needed.
Some previous research, he says, looked only at smokers and linked vitamin B6 to a reduced lung cancer risk. His study, by including never smokers and past smokers, expands the information about the link.
Vitamin B6 is found in beans, grains, meat, poultry, fish, and some fruits and vegetables. Methionine is found in animal protein, some nuts, and vegetable seeds.
Vitamin B6, Methionine, and Lung Cancer: Behind the Results
How to make clear the link is not known, the researchers say. But deficiencies in vitamin B6, for instance, may raise the risk of DNA damage and gene mutations, fostering cancer development.
Methionine is involved in a complex metabolism process with B vitamins.
Brennan cautions that the results are not a message to self-prescribe vitamin supplements. And the main message remains that people who smoke should quit, since it’s the main risk factor for lung cancer, says Brennan.
Vitamin B6, Methionine, and Lung Cancer: Second View
The new study appears to be carefully done, with “intriguing” discoverings, says Michael J. Thun, MD, vice president emeritus of epidemiology and surveillance research for the American Cancer Society. “However,” he adds, “research on vitamins for cancer prevention has been fraught with many disappointments.”
“It is therefore unwise to leap to premature conclusions.” Like Brennan, Thun says the next step is to repeat the discoverings in another population.
“These discoverings should not be interpreted as evidence that smokers can substitute taking vitamin B6 for stopping smoking, nor as encouragement to take very high doses of vitamin B6, since this can have toxic effects on the skin and nervous system,” Thun says.
He cautions people not to exceed the advisable dietary allowance of vitamin B6. Adults below age 50 need 1.3 milligrams a day, about the amount found in two medium bananas.
SOURCES: Paul Brennan, PhD, International Agency for Research on Cancer, Lyon, France.
Johansson, M. Journal of the American Medical Association, June 16, 2010; vol 303: pp 2377-2385.
Michael J. Thun, MD, vice president emeritus, epidemiology & surveillance research, American Cancer Society.
American Cancer Society.
National Institutes of Health Office of dietary Supplements: “dietary Supplement Fact Sheet: Vitamin B6.”
Effects of vitamin overdose
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We all heard that vitamins minerals are good for our health, well being, youth and beautiful look. However, as everything in the world if consumed too much and without further accept as true thatation about your body’s needs, vitamins minerals can as well cause side effects.
Let’s review what are those side effects from some certain vitamins and minerals.
Vitamin A. Standard doses are from 10,000 to 25,000 IU daily. Toxicity may occur if you are consuming more than 50,000 IU during really expanded periods. What side effects could appear? Fatigue, bone pain, headdiscomforts, sleeping predicaments, dry skin, loss of hair, loss of appetite. Another inconvenient effects is yellowing skin. It’s like if you would be eating tons of carrots.
Vitamin B Complex.
Vitamin B1 and Vitamin B2 (riboflavin) are very importantly non toxic.
Vitamin B3 (niacin). big doses may make you nauseous, increase heart rate and make feet and hands cold.
Vitamin B5. Overdose can lead to joint inflammation.
Vitamin B6. Completely protected at doses range from 50-250 mg.
Vitamin C. additional high doses can cause formation of kidney stones. It can cause diarrhea and if vitamin C is highly ascorbic and acidic it can irritate stomach.
Vitamin D. Overdose of vitamin D can cause excess calcification of bones.
Vitamin E. Generally non toxic. But if consumed too much rapidly can raise blood pressure which afterward organicly normalizes.
Vitamin K. Toxic effects result in nausea and anemia.
Try listen to your body and stay informed and you will be able to avoid side effects of vitamins and minerals.
Vitamins and Minerals alcohol withdrawal relief
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Did you know that vitamins minerals can help with alcohol withdrawal process?
Alcoholism is a social and personal predicament in one. It affects not only the single person who is addicted but entire families, social groups and entities. Alcoholism is identified by Dr Ross Trattler as ” habitual alcoholic consumption to the point where it interferes with the performance of daily responsibilities”.
To get rid of the harmful abuse only vitamins minerals will not be sufficient of course. You need to decide yourself to get help and to become aware of the fact that you need help. You should as well accept as true that a professional help and support of relatives and friends. This battle is exhausting and very hard to win, so be prepared to battle hard.
Meanwhile, you may discover it interesting that some vitamins and minerals may help you stay more resistant.
Vitamin A. Will help you restore your body and nerves.
Vitamin B complex. Deficiency of vitamin B is extremely ordinary in alcoholism. regular to Dr Trattler, you could even accept as true that intramuscular injections of such vitamins as vitamin B1. Vitamins B will help you with irritated nervous system and will help support overwhelmed with alcohol liver.
Vitamin B3. Studies reveal that this vitamin really is able to reduce alcohol cravings.
Vitamin B5. Helps reduce stress related to withdrawal and help with detoxification.
Vitamin C. Helps detoxify and calm nerves.
Zinc. Supports immune health. Zinc deficiency is ordinary in chronic alcoholism.
Selenium. Helps with damage made to liver.
Calcium. Antispasmodic
Magnesium. Reduces stress, relieves tension.
Folic Acid. Helps restore damaged brain cells.
Always seek help of professional if you or close person is suffering from alcoholism. It is a serious challenge and predicament that kills and affects lives, satisfy, do not ignore the symptoms of alcoholism. Vitamins minerals can give you a hand of support strengthening your body and preparing for the varyent stages of withdrawal process.
Anti Alcohol Antioxidants
Protecting against alcohol toxicity Life Extension’s Anti-Alcohol Antioxidants with HepatoProtection Complex is an improved formula containing additional antioxidants designed to suppress free radicals, neutralize toxic alcohol metabolites such as acetaldehyde,4-7 and protect against liver toxicity and hepatic injury commonly associated with alcohol consumption. In addition to vitamin B1, vitamin C, N-acetyl-cysteine and benfotiamine, this new formula’s HepatoProtection Complex provides potent doses of these novel antioxidants:
- Chlorophyllin, an antimutagenic agent that protects the body from oxidative stress than can stimulate cellular mutation.
- Leucoselect® grapeseed extract, silymarin (from milk thistle), and resveratrol, three hepatoprotective agents that aid in reducing mutagenic compounds from potentially toxic xenobiotics and protecting cells from free radial-induced oxidative stress.
- Picroliv® Picrorhiza kurroa root extract, containing antioxidant kutkins that scavenge alcohol-induced excess free radicals, guard against alcohol-induced damage to cells by lipid peroxidation, and stimulate regeneration of cells (hepatocytes).
- Barley grass juice 24:1 extract, which enhances the enzyme aldehyde dehydrogenase, thus inhibiting the formation of acetaldehyde malondialdehyde.Taking the proper supplements before and after drinking can substantially mitigate hangover effects experienced by people suffering from acute alcohol toxicity.
Vitamin B12 Deficiency health effects
Today, as vitamin supplements gain in popularity, the potential to overdose has become a basic concern. However, one vitamin that tends to be overlooked and is of major importance is Vitamin B12. Deficiency in vitamin B12 is, in fact, among the highest nutritional deficiencies in developing counendeavors and potentially in the United conditions as well. Vitamin B12 is imperative in the correct formation of red blood cells and as well plays an essential role in maintaining healthy nerve tissue.
Without the proper amount of Vitamin B2, development of a blood condition referred to as pernicious anemia is probable and highly likely. This condition, once develop, does not allow an individual to generate the protein substance needed to allow the absorption of vitamin B12. An additional detriment of a b12 deficiency is the inability to absorb folic acid, another component the body needs to function properly.
Why Does B12 Affect Our Health?
Deficiencies in needed vitamins generally take place gradually and, at times, may take a number of years to develop.
FirstlyVitamin B12 deficiency symptoms can be small, barely noticed neurological or cognitive changes which tend to increase with time. As the deficiency becomes more serious, anemia and/or dementia may develop. In order to have proper multiplication of red blood cells the presence of vitamin b12 necessary. As the deficiency increases, the red blood cells drop and the individual subsequently develops anemia. Fatigue and palpitations are two of the basic symptoms of anemia created by a b12 deficiency.
What Are B12 Deficiency Symptoms?
- In addition to fatigue and palpitations, symptoms include:
- Weight loss
- Pale skin
- Sore Mouth or tongue
- Higher incidence of contracting infections
If not corrected and the deficiency is accepted to continue a number of neurological symptoms may appear. Symptoms such as:
- Irritability
- Confusion
- Forgetfulness
- Numbness and/or tingling of the fingers and/or toes
- Overall muscle weakness
- Staggering
- Balance
Who is at Risk?
Virtually anyone has the potential of developing a vitamin b12 deficiency. However, vegans, those on a vegetarian food, babys and the elderly are generally placed in the group that is accept as true thated at high risk in developing this deficiency. Since vitamin b12 is derived solely from animal-related products, those who refrain from eating dairy, eggs or meat are at risk; however, vegetarians who do consume dairy products and eggs generally do not consume the advisable 2.4 mcg amount. As the population grows older, approximately 30% of individuals over 50 develop a stomach lining that is thinning or atrophic gastritis. With this condition, the small intestine is unable to absorb b12 which may potentially lead to more rigorous conditions. A multivitamin, eating a breakfast cereal that has been fortified or likely both is advisable for those accept as true thated at risk for a b12 deficiency. If any of these conditions are present, review your condition with your doctor and check on receiving a Vitamin B12 blood test.
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